Recent advances in DNA-based probes for photoacoustic imaging.

Photoacoustic imaging(PAI) is a widely developing imaging modality that has seen tremendous evolvement in the last decade. PAI has gained the upper hand in the imaging field as it takes advantage of optical absorption and ultrasound detection that imparts higher resolution, rich contrast and elevated penetration depth. Unlike other imaging techniques, PAI does not use ionising radiation and is a better, cost-effective and healthier alternative to other imaging techniques. It offers greater specificity than conventional ultrasound imaging with the ability to detect haemoglobin, lipids, water and other light-absorbing chromophores. These properties of PAI have led to its extended applications in the biomedical field in the treatment of diseases such as cancer. This paper reviews how DNA probes have been used in PAI, the various techniques by which it has been modified, and their role in the process. We also focus on different nanocomposites containing DNA having PAI and photothermal therapy(PTT) properties for detection, diagnosis and therapy, its constituents and the role of DNA in it.

Recent advancements in Janus nanoparticle-based biosensing platforms.

Nanoparticles have aided in the development of nano-based sensors for diagnostic applications. However, use of nanoparticles in the development of sensing devices for multiple analyte detection is constrained due to their inability to detect several analytes with a single type of nanoparticle. The term "Janus particle" refers to micro or nanoscale particles that have been divided into sections or compartments, each of which has a distinct set of chemical or physical properties, producing multifunctional particles endowed with distinctive qualities. Furthermore, Janus particles have the ability to perform multiple functions within a single particle at the same time, with no interference from adjacent sections. This review focuses on the use of Janus particles in the fabrication of biosensors as well as in the investigation of various properties endowed by these Janus particles for their use as biosensors. It also discusses the various types of Janus particle-based biosensors that are currently available. Finally, the limitations of Janus particles in sensor technologies and their future scope have been discussed.

Quantum Dots Based Fluorescent Probe for the Selective Detection of Heavy Metal Ions.

Heavy metal ions are one of the primary causes of environmental pollution. A marshal effect of heavy metal ions is a paramount ultimatum to humans, aquatic animals and other organisms present in nature. Multitude arrays of materials have been proclaimed for sensing of heavy metal ions and also many methodologies are applied for heavy metal ion sensing. Due to their toxicity and non-biodegradability, it is required to be perceived immediately prior to its manifestation of harmful effects. Quantum Dots (QDs) are zero-dimensional nanomaterial particles and owing to their distinctive optical and electronic properties, they are utilized as nanosensors. QDs have enriched fluorescence properties which includes broad excitation spectrum, narrow emission spectrum and photostability. QDs offer eclectic and sensitive detection of heavy metal ions due to presence of discrete capping agents and different functional groups present on the surface of the QDs. These capping layers and functional groups attune the sensing capability of the QDs, which leverages the interactions of QDs with various analytes by different mechanisms. This review, comprising of papers from 2011 to 2020,focuses on heavy metal ions sensing potential of various quantum dots and its applicability as a nanosensor for on field heavy metal ions detection in water. Quantum Dots (QDs) based Heavy Metal Detection.